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Chimerism and Neutrophils Down what is going on?
just wondering if anyone had any experience of the following.
My husband had transplant 15 Feb 2019 now on day 172. He had AML & ALL diagnosed 5 Sept 18.
Everything was going well, but his chimerism has been dropping, (40%) now neutrophils have started dropping. He had bone marrow taken no Leukaemia seen. Consultants wanted to do top up DLI.
No virus seen in blood. He is off all cyclosporine
I have been giving the injections in his stomach every other day his neutrophils did go up. Consultants then wanted to hold off DLI as they thought Donor might be coming through, so injections were stopped. But neutrophils have dropped again and chimerism has gone up to 45%%. ??He currently has horrendous mouth ulcers and white coating of the tongue can’t talk, but no bacteria found so I’m thinking GVHD. Has anyone had this experience we just can’t move forward. Many Thanks